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The outermost layer of the skin, known as the stratum corneum SC , is composed of dead corneocytes embedded in an intercellular lipid matrix consisting of ceramides, free fatty acids, and cholesterol. The high level of organization within this matrix protects the body by limiting the permeation of most compounds through the skin. While essential for its protective functions, the SC poses a significant barrier for the delivery of topically applied pharmaceutical agents. Chemical permeation enhancers CPEs can increase delivery of small drug compounds into the skin by interacting with the intercellular lipids through physical processes including extraction, fluidization, increased disorder, and phase separation. However, it is not clear whether these same mechanisms are involved in delivery of biotherapeutic macromolecules, such as proteins.


Search the history of over billion web pages on the Internet. Books by Language. Julius Zupitza s Alt It has survived long enough for the copyright to expire and the book to enter the public domain. A public domain book is one that was never subject to copyright or whose legal copyright term has expired. Whether a book is in the public domain may vary country to country. Public domain books are our gateways to the past, representing a wealth of history, culture and knowledge that s often difficult to discover.

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You can search through the full text of this book on the web at http: Set up and electrotyped November, Reprinted February, Z; November, ; March, 19x1. Cnthinc Je Co. Of Verses from the Ruthwbll Cross Of a Riddle xzx V. Of the Genesis zxxi VI. Of the Judith xzzii VIl. Of a Legal Document xzziv Vin. Of Alfred s Account of Cjedmon zzxviii X. Of the.

Of Matthew, Chap. Of John, Chap. XXI xly Xm. Of the Jacob and Esau xlyl Xrv. Of the Samson xlvii XV. Of the Poema Morale xlix XVn. Of the Orrmulum li XIX. Or A Homily on the Miracle at Cana. Iv XXIV. Of the Hayelok. Ivi XXVI. Of the Cubsor Mundi. AND ME. Vebses fbom the Cboss at Ruthwbll 2 IV. A Riddle 4 V. From the Genesis 5 VI. From the Judith 8 VII. Specimen of a Legal Document, a.

Matthew, Chap. John, Chap. Jacob and Esau 39 XIV. Samson 42 XV. From Gbnesis and Exodus 76 XXn. From Dan Michel s Atenbite of Inwtt. The Beginning of the V. From John Ltdgate s Gut of Wabwick Among the recent Readers in this field it is one of a new type, or perhaps better, it is a reversion with the modi- fications of late research to the primitive type represented by works like Bask s PraviSy Thorpe s Aiiolectay March s BeadeTy or Corson s Hand-book.

Like its original it is emphati- cally an ExercUe Book. Like that it is concise but com- prehensive. Unlike its original, in order to meet the requirements of English-speaking teachers and pupils, it is supplied with illustrative etymologies, cognate words, phonological equations, necessary historical and literary introductions, and bibliographical references. All these put together cannot make up for the loss of the German pro- fessor s lectures, but they suggest the points he covers, and may make it possible for others to arrive at the same goal with him, and with the added pleasure of having done the work for themselves.

The book is of a new type in its appeal to scholars of the most diverse views. For the philologist and devotee of phonology it has some of the results and the method of the new school of Com- parative Philology in Germany and England, and it has them in concrete examples and condensed form for the initiation of beginners. The time has come to make Old English available for those of English speech as the nat- ural point of departure for the study of Comparative Phi- lology.

We have not been unmindful of the words of Eask: But this circumstance renders it still more necessary to German scholars ; to them Anglo-Saxon is almost what the Icelandic is to those of Denmark, Sweden, and Norway. But it is to the English philologist that the Anglo-Saxon, as being his old national tongue, is of the greatest moment. To him it is precisely what Icelandic is to the modem Scandinavian and Latin to the Ital- ians. Even Dr.

Johnson was aware of this. For the mere literary student the selections offer mate- rial for a brief comparative study of literature. The evolu- tion of both poetry and prose is suggested. Till entire period. The introductions are in part designed to correlate the extracts and to relate them to literary history. For the practical teacher and hurried pupil, who know that they must have at least the elements of Old English to understand the Modern, here is a book which in the space ordinarily given to Old English alone connects the Old through the necessary link of Middle English to the Modem tongue.

My obligation is enhanced by the value of services rendered to me, beginning with my instruc- tion under Professors Wdlker and Zupitza. Professor Zupitza is in no way responsi- ble for the gilding with which I have overlaid his pure gold. I am glad to have this occasion to acknowledge the many kindnesses of Professor Skeat, and in particular his send- ing to me the advanced sheets of his Principles of English Etymology, Likewise I am obliged to Professor T.

Northcote Toller for advanced sheets of the Bosworth and Toller A. Dictionary, and to Mr. Balg, Ph. Gregory Foster, Ph. Wright, and Messrs. Morfill and Wink- field. Furthermore, without the British Museum and the well-known courtesies of its authorities and attendants, my work could hardly have been accomplished. Triggs, M. Yersificatioiiy and is to be credited very largely for the his- torical introductions in ME. Last, and by no means least, I must pay hearty tribute to the devoted clerical service of my wife, Clara Taylor.

She alphabetized the Glossary, transcribed much of the copy, verified references, and assisted in proof-reading. The printer and I owe much to her fair hand. May not the imperfections of my work prevent Messrs. In using the Reader, many teachers may take it for beginners. They wish to dispense with Primers, considering that the pupils in Old English are apt to be mature and to have a degree of linguistic discipline. Such teachers will do well to assign the selections in the follow- ing order, proceeding from the Late WS.

The transition to ME. In the distinctively ME. XVI to XXXIV one can hardly do better than to follow them, with such curtailment as time may require, in the chronological order in which they stand. X and XVI are difficult.

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Search the history of over billion web pages on the Internet. Books by Language. Julius Zupitza s Alt It has survived long enough for the copyright to expire and the book to enter the public domain. A public domain book is one that was never subject to copyright or whose legal copyright term has expired. Whether a book is in the public domain may vary country to country.

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